Bronchitis Disease - Symptoms And Genetic Aspects Of Bronchitis And Emphysema
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Symptoms And Genetic Aspects Of Bronchitis And Emphysema

A simple cough mustn't be ignored. If this cough transforms into a persistent productive cough with an excessive airway mucus secretion we can think that it is bronchitis. if the process becomes chronic and the cough and sputum persists for minimum three or six months during one or two years with very short periods in which the cough disappears, the diagnosis is sure. All this symptoms leads to the diagnosis of Bronchitis, a disease of the lungs from the COPD category. In Bronchitis the large and small airways can be obstructed and it becomes very difficult to move air in and out of the lungs.


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 Another aspect is the deficiency of alpha-1-antitrypsin. This deficiency is caused by the loss of elastin which is a structural protein. All this leads to Emphysema. Because elastin is involved in the maintenance of the strength of the alveolar walls, in Emphysema there will be a permanent destruction of the alveoli.

There is a form of Emphysema influenced by a long period of smoking called "Smoker's Emphysema". It develops usually in older patients. Another type of Emphysema is the one with a hereditary transmission. In this case there is a deficiency of alpha-i-antitrypsin (AAT), but just one to three percent of all cases of Emphysema are due to AAT deficiency. This happens because in the lungs, at cells level there is an imbalance between elastin and AAT. The reaction between this two proteins is mediate by an enzyme called elastase. When there is a genetic deficiency of AAT the elastin degradation occurs unchecked. This phenomenon is worsen if the patients with genetic deficiency of AAT smoke and the symptoms appears early middle age. The deficiency of ATT is detected by blood tests made in specialized laboratories.

 
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Regarding Smoker's Emphysema and the hereditary one studies showed that in the lungs cells the mechanism is the same. One of the tobacco smoking effects is the elastese-AAT imbalance. The explanation is that smoking stimulates excessively release of elastase. There was also confirmed the theory that the inhaled smoke stimulates the migration in the lungs of the elastase producing cells. Another aspect of smoking is the effect of the oxidants from the cigarette smoke. The antioxidants inactivate a significant portion of the elastase inhibitors and as a consequence it is upsetted the elastase-antielastase balance. But there are also other factors in addition to smoking effects that influences the development of Emphysema. Nowadays the effect of these other factors is not very clear. There was estimated that only twenty percent of smokers develop Emphysema.



For more resources on bronchitis or especially about acute bronchitis please click this link http://www.bronchitis-guide.com/acute-bronchitis.htm

 
 
     
 
 





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Bronchitis is a respiratory ailment that can happen at all ages. It scares all the parents as they do not want their children to be afflicted with the ailment. A key identification of this ailment is inflammation of a person s bronchi that is a part of our lungs. First of all, the parents and/or caregivers can calm down as the medical findings have proved that bronchitis among children is...


What is Bronchitis? Bronchitis is defined as an inflammation of the bronchi. Bronchi are airways in the respiratory tract that bring air into the lungs. This inflammation is typically caused by viruses or bacteria, but it may also be caused by inhaled irritants, such as cigarette smoke or harmful chemicals. Most cases of bronchitis cases involve a viral pathogen. The inflammation is...


Bronchitis usually refers to an acute inflammation of the air passages in your lungs. The airways that connect the windpipe (trachea) to the lungs. It causes coughing, shortness of breath and chest tightness. Cough is often yellow or green mucus. There are two main types of bronchitis: acute and chronic. Acute bronchitis is often caused by the same viruses that cause colds. It usually begins as a...


Bronchitis is an acute inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes. The disease comes in two forms: acute (lasting less than 6 weeks) and chronic (reoccurring frequently for more than two years). In addition, people with asthma also...


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